What Probara covers.

Ingredient categories and outcome types with sufficient evidence in our corpus. If an ingredient is not covered, the API says so explicitly.

Coverage is determined by the volume, quality, and consistency of peer-reviewed human trials indexed in PubMed. An ingredient-outcome pair is considered "covered" when there is sufficient evidence to assign a GRADE and produce a signed card. Below the coverage threshold, the API returns evidence_coverage_insufficient rather than a low-confidence card.

Covered ingredient categories

Core vitamins
Vitamin D3, Vitamin C, Vitamin B12, Vitamin K2, Folate
Essential minerals
Magnesium, Zinc, Selenium, Iron, Iodine
Amino acids
Creatine monohydrate, L-Glutamine, Beta-Alanine, Taurine, L-Carnitine
Omega fatty acids
Omega-3 (EPA/DHA), Fish oil, Flaxseed oil
Well-studied botanicals
Ashwagandha, Berberine, Curcumin, Ginkgo biloba, Rhodiola rosea
Prebiotics and probiotics
Selected Lactobacillus strains, Bifidobacterium, Inulin, FOS

Covered outcome types

Cognitive Memory, focus, reaction time, executive function. Measured via validated cognitive assessments.
Sleep Sleep latency, total sleep time, sleep quality scores, polysomnography endpoints
Physical performance Strength, power output, VO2 max, muscle mass, endurance. Measured via standardized tests.
Metabolic markers Blood glucose, HbA1c, lipid panels, insulin sensitivity. Lab-measured endpoints.
Inflammatory markers CRP, IL-6, TNF-alpha. Blood-panel endpoints with consistent measurement.
Mood and stress Cortisol, validated anxiety/depression scales (PHQ-9, GAD-7, PSS)

Not yet covered

These categories are outside current coverage. The API returns evidence_coverage_insufficient for any request in these areas. We prefer an honest error over a low-confidence card.

Proprietary blends and multi-ingredient stacks (requires each ingredient to be evaluated independently)
Novel or recently-launched compounds with fewer than 3 independent human trials
Traditional herbal medicines without PubMed-indexed clinical trials in the specific indication
Pediatric, pregnancy, and geriatric-specific dosage endpoints (population coverage is in progress)
Check coverage via API
GET /v1/coverage?ingredient=creatine&outcome=muscle_strength
Authorization: Bearer <your-key>

# Returns: covered: true | false + grade if covered